Abnormal exertional breathlessness on cardiopulmonary cycle exercise testing in relation to self-reported and physiological responses in chronic airflow limitation

Ekström, Magnus; Li, Pei Zhi; Lewthwaite, Hayley; Bourbeau, Jean; Tan, Wan C.; Jensen, Dennis; ., CanCOLD Collaborative Research Group

Title: Abnormal exertional breathlessness on cardiopulmonary cycle exercise testing in relation to self-reported and physiological responses in chronic airflow limitation
Creator: Ekström, Magnus; Li, Pei Zhi; Lewthwaite, Hayley; Bourbeau, Jean; Tan, Wan C.; Jensen, Dennis; ., CanCOLD Collaborative Research Group
Relation: Chest Vol. 166, Issue 1, p. 81-94
Publisher Link: http://dx.doi.org/10.1016/j.chest.2024.02.034
Publisher: American College of Chest Physicians
Resource Type: journal article
Date: 2024
Description: Background: Exertional breathlessness is a cardinal symptom of cardiorespiratory disease. Research Question: How does breathlessness abnormality graded using normative reference equations during cardiopulmonary exercise testing (CPET) relate to self-reported and physiological responses in people with chronic airflow limitation (CAL). Study Design and Methods: Analysis of people aged ≥40 years with CAL undergoing CPET in the Canadian Cohort Obstructive Lung Disease study. Breathlessness intensity ratings (Borg 0-10 category ratio scale [CR10]) were evaluated in relation to power output (W), rate of oxygen uptake (V'O2), and minute ventilation (V'E) at peak exercise using normative reference equations as: 1) probability of breathlessness normality (probability of having an equal or greater Borg CR10 rating among healthy; lower probability reflecting more severe breathlessness); and 2) presence of abnormal breathlessness (rating above the upper limit of normal [ULN]). Associations with relevant participant-reported and physiologic outcomes were evaluated. Results: We included 330 participants (44% women): mean±SD age 64±10 years (range 40-89), FEV1/FVC 57.3±8.2%, FEV1 75.6±17.9%predicted. Abnormally low exercise capacity (peak V'O2
Subject: dyspnea; exercise capacity; exercise test; reference values; SDG 3
Identifier: http://hdl.handle.net/1959.13/1509592
Identifier: uon:56268
Identifier: ISSN:0012-3692
Rights: X
Language: eng
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